Serocef Tablet

Mechanism of Action-

CLINICAL PHARMACOLOGY & ANTI-MICROBIAL SPECTRUM

As with other cephalosporins, bactericidal action of cefixime results from inhibition of cell-wall synthesis. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.

PHARMACOKINETICS

Cefixime given orally, is about 40%-50% absorbed from the GI tract. The mean elimination half-life (t1/2) of 3h. Urinary excretion accounts for between 12 and 34% of an orally administered dose. Cefixime is not removed to a significant degree by either peritoneal dialysis or haemodialysis. Cefixime is mainly excreted unchanged in bile and urine.

INDICATIONS

* Urinary tract infections * Upper and lower respiratory tract infections * Acute otitis media * Gonococcal urethritis

DOSAGE AND ADMINISTRATION Adults & Children [weighing more than 50 kg or older than 12 yr of age] :

200-400 mg in single or divided doses.

Children 6 mo to 12 yr of age [or weighing under 50 kg]:

once-daily dose or in 2 divided doses of 4 mg/kg every 12 h.

CONTRAINDICATIONS

Cefixime is contraindicated in patients with a known hypersensitivity to cephalosporin group of antibiotics.