R-Fred-D Capsules

Mechanism of Action-

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton- pump inhibitors) that do not exhibit anticholinergic or histamine H2 -receptor antagonist properties.

Rabeprazole block gastric acid secretion by inhibiting gastric H+/K+-adenosine triphosphatase in gastric parietal cells.

Domperidone is dopamine antagonist that increases gastric emptying, small bowel transit, and the tone of the lower oesophageal sphincter.

INDICATIONS

R-Fred-D Capules are indicated for relieving Gastro-oesophageal reflux disease, Hypersecretory conditions, Active peptic ulcer disease, H.pylori infection etc.

DOSAGE AND ADMINISTRATION Gastro-oesophageal reflux disease (oral)

Adult: For erosive oesophagitis: 20 mg once daily in the morning for 4-8 wk. Maintenance: 10-20 mg once daily according to response. For non-erosive oesophagitis: 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when necessary or as prescribed.

Hypersecretory conditions (oral)

Adult: Initially, 60 mg daily adjusted according to response. Max dose: 120 mg daily or as prescribed.

Active peptic ulcer disease (oral)

Adult: 20 mg daily given for 4-8 wk for duodenal ulcer and 6-12 wk for gastric ulcer or as prescribed.

H.pylori infection

Adult: As a combination with two antibacterials: 20 mg bid combined with clarithromycin 500 mg bid and either amoxicillin 1 g bid or metronidazole 400 mg bid. To be taken for a week or as prescribed.

HOW SUPPLIED

10 Capsules per strip